The TRACERlab FX2 N, evolution of the TRACERlab FX N Pro, is a fully automated two-reactor system for easy and efficient production of [18F] tracers starting with [18F]Fluoride from a cyclotron (e.g. PETtrace* or MINItrace*) via a nucleophilic reaction.

TRACERlab FX2 N combines flexibility and productivity. The synthesis sequence can be user defined in order to produce the desired tracer. It includes an HPLC purification and formulation system.

More than 70 tracers have been produced and published using the predecessor products of TRACERlab FX2 N and TRACERlab FX2 N can run all these synthesis methods too.

Tracer lab.


Flexible, efficient [18F] tracer synthesis TRACERlab FX2 N allows you to:

  • Improve productivity with fully automated production steps
  • Increase flexibility with user-defined synthesis sequence
  • Log complete process history for traceability
  • Control access with password protection system
  • Acquire production reports that include lot numbers, vial process parameters, etc.
  • Minimize radioactive material generation
  • Minimize your interaction when radioactivity is present


The TRACERlab FX2 N integrates all the necessary steps for the production of [18F] tracers starting with [18F]Fluoride:

  • Phase transfer of the [18F]Fluoride and [18O]water recovery
  • Two independent reactors with heating and cooling and stirring facility. Retractable reactor needle.
  • Direct transfer from reactor 1 to reactor 2 or via solid phase extraction
  • Built-in semi-preparative HPLC purification
  • Built-in formulation of the final tracer
  • Liquid system sealed against room air

All production steps are fully automated.



System Characteristics

Size (W x H x D) of main module 50 cm x 48 cm x 50 cm
Weight of main module 25 kg
Control electronics 29 cm x 21 cm x 8.5 cm
5 Radiation detectors [11F]Fluoride, at the two labelling reactors, HPLC, product vial
Reactor 1 Glassy Carbon, 20 mm ID, heating up to 200°C, air cooling. Retractable reactor needle.
Reactor 2 Borosilicate glass, 9 mm ID, V-shape, heating up to 200°C, air cooling to ambient temperature.
Retractable reactor needle.
Reagent vials 6 connected to reactor 1
5 connected to reactor 2
3 for formulation
Purification subsystem Isocratic HPLC controlled by the synthesis software
Gamma radiation and UV (190-500 nm D2) detectors
Formulation subsystem Solid phase extraction with stirred dilution flask
Cyclotron interface Two target connections for working with two [18F]Fluoride targets and a choice of 2 target vials sizes: 5 or 10 ml for maximum flexibility.